Endocrine Abstracts

Background: Craniopharyngiomas (CPs) are epithelial tumors that typically arise in the suprasellar region. They are associated with high levels of morbidity related to tumour location and/or treatment-related injuries. Recent discoveries have also led to a better understanding of CP development and potential treatments.Objetive: To analyse the clinical, pathological, molecular features and outcomes of patients with CP.Design: Retro...

A 50-year-old woman with no history of interest who was admitted in hospital for progressive headache 2 weeks of evolution refractory to treatment that was accompanied by emetic syndrome and paresthesias in face and arms. A CT scan of the skull (urgency) was performed which was normal. Neurology improves with analgesia and steroids, presenting mild drowsiness and mild hyponatremia (121 mEq/l). A cerebral MRI was performed, showing a right subacute hemorrhagic adenoma of 1 cm t...

Introduction: The prevalence of pituitary thyrotropin secreting tumors (TSH-omas) is 1-2 cases per million inhabitants, most of them being macroadenomas. The differential diagnosis may be challenging, especially for microadenomas.Case Report: A 50-year-old male was observed at the endocrinology department with multinodular goiter. He noticed progressive neck enlargement over the previous months but denied other complaints. There was no family history of ...

Abstract: We report the case of a 65-year-old man who presented with erectile dysfunction to an appointment in our Endocrinology department. He referred fatigue, weight gain and constipation as secondary complaints that had been steadily evolving throughout the past 4 years. He denied other symptoms such as visual impairment or headaches as well as the consumption of any medications or drugs. His past medical history was unremarkable. On examination, BMI was 25.8 kg/m2</s...

Introduction: Pituitary apoplexy is a rare disease which results of haemorrhage and/or infarction of pituitary gland. The optimal management of this problem still remains controversial between surgery and conservative treatment.Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow up of patients with apoplexy. Methods:Retrospective study of 35 pituitary apoplexy followed in a portuguese hospital from 2006 to 2016.<p...

Introduction: Inferior Petrosal Sinus Sampling (IPSS) is the gold standard test to distinguish between Cushing Disease and ectopic ACTH secretion (EAS), mostly when the biochemical tests are discordant and/or there is no lesion in MRI.Aim: To evaluate the results of IPSS in the diagnosis of ACTH-dependent Cushing syndrome.Methods: Retrospective study that analysed IPSS results performed in the last decade in our centre and integrat...

Postpartum thyroid dysfunction occurs in 5–10% of women in the general population within one year of delivery. The prevalence of postpartum Graves’ disease is estimated at 0.54%. Postpartum thyroiditis is much more common. Differential diagnosis is essential for an adequate treatment. Radioactive iodine uptake can be useful to establish the etiologic diagnosis, but is contraindicated during lactation. Elevated titers of antithyrotropin receptor antibodies (TRAbs) are...

Introduction: Hypothyroidism can affect the nervous system, commonly causing mono and polyneuropathies which show a variable frequency and pattern. Its mechanisms are not fully understood. Symptoms usually correlate better with the duration of the dysfunction rather than with its severity and typically improve significantly after medical therapy.Case report: A 58-year-old woman was admitted at our hospital with a one-year history of progressive weakness ...

Introduction: Radioiodine treatment (RAIT) is an effective definitive treatment for Graves’ Disease (GD) and Toxic Nodular Goiter (TNG). The aim of this study was to analyze demographic and clinical factors affecting the outcome of RAIT in patients with hyperthyroidism.Methods: Retrospective review of patients treated with RAIT for hyperthyroidism. A fixed dose of 10 mCi was administered to patients with GD and 15 mCi to patients with TNG. Treatment...

Introduction: Clinically non-functioning pituitary adenoma (NFPA) represents up to 30% of pituitary tumours. Management is dictated by their size or mass effect. The natural progression of NFPA attracts debate as the evidence-base is limited.Methods: Conservatively managed NFPA patients were included. A single radiologist reviewed all images to avoid bias.Results: Forty-six patients were identified, 21 female. Four presented acutel...